Signal transduction in pancreatic stellate cells
نویسندگان
چکیده
منابع مشابه
PDGF and signal transduction in hepatic stellate cells.
Platelet-derived growth factor (PDGF) is one of the most potent mitogen for cultured HSC isolated from rat, mouse, or human liver. Phosphotyrosines on the activated PDGF receptor operate as high affinity binding sites for several molecules involved in the downstream propagation of the signal, including the sequential activation of Raf-1, MEK and extracellular-signal regulated kinase (ERK). Nucl...
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Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic in...
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Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the ...
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Proliferation and matrix synthesis by activated pancreatic stellate cells (PSC) participate in the development of chronic pancreatitis. Apoptosis of PSC may terminate this process but has not yet been studied in this particular cell type and was the aim of the present study. PSC were isolated from rat pancreas and characterized for expression of glial fibrillary acidic protein, alpha-smooth mus...
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Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alteratio...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology
سال: 2009
ISSN: 0944-1174,1435-5922
DOI: 10.1007/s00535-009-0013-2